Principal Scientist/Sr. Scientist - In Vitro Pharmacology Contractor

Company: Lexeo Therapeutics
Location: San Diego
Posted on: June 1, 2025

Job Description:

Lexeo Therapeutics is seeking a Principal Scientist/Sr. Scientist to join our Discovery & Translation team in San Diego, CA. The individual in this role will be responsible for designing and implementing experiments using iPSC-derived cardiomyocytes or other relevant cell lines to support the discovery and development of novel therapeutics for cardiac disease. This role requires expertise in cell culture techniques, cell differentiation, a strong background in molecular biology, and experience in optimizing high-throughput screening platforms. This is a hands-on laboratory role with the successful candidate also contributing to research strategy.
Primary Responsibilities

• Identify relevant in vitro systems to support drug discovery for innovative cardiac targets
  
• Design and optimize protocols for efficient and reproducible differentiation of iPSCs into cardiomyocytes
  
• Design, execute, and interpret in vitro screening studies, including the application of high-throughput screening assays, to advance drug discovery efforts
  
• Employ a variety of cellular and molecular assays (e.g., imaging, qPCR/ddPCR, western blot, MSD) to support drug discovery efforts
  
• Analyze and interpret data from in vitro studies to provide recommendations to internal stakeholders
  
• Stay up to date on the latest advances in in vitro modeling and consider opportunities to apply novel technologies/techniques for discovery research
  
• Collaborate within and across teams to advance drug discovery and development projects
  
• Maintain current, detailed documentation of experimental designs, results, and analyses using an electronic laboratory notebook
  
  Required Skills & Qualifications
  
  
• Ph.D. in Biology, Biomedical Sciences, Bioinformatics, Computational Biology, or related field with 0-3 years of post-graduate research experience
  
• Knowledge and experience using bioinformatics workflows
  
• Experience with RNA-seq analysis, including QC, normalization, and differential expression analysis
  
• Hands-on experience with a variety of cellular systems; experience with cardiomyocytes is a plus
  
• Deep knowledge of cellular and molecular biology techniques (e.g., flow cytometry, imaging, RNA/DNA isolation, ddPCR, western blot)
  
• Must be able to effectively document research efforts in an electronic laboratory notebook
  
• Excellent communication, presentation, and project management skills with the ability to effectively convey scientific findings to key internal stakeholders
  
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Keywords: Lexeo Therapeutics, El Centro , Principal Scientist/Sr. Scientist - In Vitro Pharmacology Contractor, Other , San Diego, California