Scientist II, Analytical Development, Bioassays
Company: Insmed Incorporated
Location: San Diego
Posted on: January 30, 2026
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Job Description:
At Insmed, every moment and every patient counts — and so does
every person who joins in. As a global biopharmaceutical company
dedicated to transforming the lives of patients with serious and
rare diseases, you’ll be part of a community that prioritizes the
human experience, celebrates curiosity, and values every person’s
contributions to meaningful progress. That commitment has earned us
recognition as Science magazine’s No. 1 Top Employer for five
consecutive years, certification as a Great Place to Work® in the
U.S., and a place on The Sunday Times Best Places to Work list in
the UK. For patients, for each other, and for the future of
science, we’re in. Are you? About the Role: We’re looking for a
Scientist II on the Analytical Development team to help us expand
what’s possible for patients with serious diseases. Reporting to
the Senior Scientist you’ll support the development of impactful
gene therapy products for patients with rare diseases. As a bench
scientist, you’ll work within a team devoted to the development of
phase-appropriate potency bioassays focused on AAV gene therapy
programs. You will be a part of a multidisciplinary team of
scientists spanning discovery research, process development, and
quality control. Additionally, this role will collaborate with QA,
clinical research, regulatory affairs, program management, legal,
and finance to advance gene therapy candidates to patients. What
You'll Do: In this role, your contributions will involve the
development, implementation, and transfer of IND-enabling
analytical methods from Analytical Development to QC and to
contracted organizations to support CMC activities. This role will
be responsible for lifecycle management of analytical methods from
Phase I to commercialization. You’ll also: Design, develop, and
execute assay development strategies to produce analytical methods
for release and stability testing in a GMP environment Serve as a
subject-matter-expert for phase-appropriate in vitro potency assays
Collaborate with research, quality control, and process development
teams to develop, transfer, and qualify early phase AAV gene
therapy cell-based biological potency assays Develop Phase
I-appropriate analytical potency bioassays and continue refinement
of methods through later phases of method lifecycle Monitor
analytical method performance Actively contribute to the enabling
and improvement of analytical development capabilities and
processes to support the Quality Team at Insmed Gene Therapy Draft
and review protocols, SOPs, development reports, and other
investigational product documents Maintain the Analytical
Development laboratory, reagents, and instruments Software Use
Expectations: JMP statistical software or equivalent software for
data analysis, assay tracking and trending, and establishment of
system and sample acceptance criteria Learn and become proficient
in all laboratory instrument software for method development
Integration of automation into existing workflows Ensure the
accurate documentation and record keeping of all lab and associated
work, in adherence with current Good Documentation Practices
Perform data review to ensure accuracy, completeness, and
reliability Participate in cross-disciplinary mentoring and
training of associate scientists Assist with coordination and
day-to-day management of site operations Who You Are: You have a BS
or equivalent, in biochemistry, cell biology or related field, with
a minimum of 5 years of relevant experience; or, Master’s degree in
relevant discipline with a minimum of 3 years of relevant
experience; or, PhD with a minimum of 1 year of relevant
experience. You are or you also have: Deep technical understanding
of, and hands-on experience with, molecular biology, recombinant
DNA technology, gene editing techniques, and cell biology Cell
culture, western blot, electrophoresis, ELISA, flow cytometry,
PCR/qPCR/ddPCR, microscopy (bright field, fluorescent, confocal,
etc.) Experience in optimizing methods with particular emphasis on
cell-based potency assays, molecular biology assays, microscopy,
and protein chemistry assay Proven track record in method
development, including experimental design, execution, and
evaluation Ability to set and meet experimental timelines, ensuring
project progression Excellent organizational and communication
skills (verbal and written), with a strong attention to detail,
clarity, accuracy, and conciseness Ability to thrive in a dynamic
work environment and show commitment to diversity in individuals
and ideas, with a strong willingness to take on new challenges
required to bring novel medicines to the clinic Nice to have (but
not required): Significant experience in an FDA-regulated
environment is a plus, specifically in the pharmaceutical industry
with a GMP testing focus Where You’ll Work This role is based out
of our San Diego office and requires full-time, in-person presence
to support hands-on collaboration, access specialized equipment,
and/or operational needs. Travel Requirements 0-15% domestic and/or
international travel required for method transfer activities and
other business-related travel LI-POST LI-MC1 Pay Range:
$127,000.00-165,500.00 Annual Life at Insmed At Insmed, you’ll find
a culture as human as our mission—intentionally designed for the
people behind it. You deserve a workplace that reflects the same
care you bring to your work each day, with support for how you
work, how you grow, and how you show up for patients, your team,
and yourself. Highlights of our U.S. offerings include:
Comprehensive medical, dental, and vision coverage and mental
health support, annual wellbeing reimbursement, and access to our
Employee Assistance Program (EAP) Generous paid time off policies,
fertility and family-forming benefits, caregiver support, and
flexible work schedules with purposeful in-person collaboration
401(k) plan with a competitive company match, annual equity awards,
and participation in our Employee Stock Purchase Plan (ESPP), and
company-paid life and disability insurance Company Learning
Institute providing access to LinkedIn Learning, skill building
workshops, leadership programs, mentorship connections, and
networking opportunities Employee resource groups, service and
recognition programs, and meaningful opportunities to connect,
volunteer, and give back Eligibility for specific programs may vary
and is subject to the terms and conditions of each plan. Current
Insmed Employees: Please apply via the Jobs Hub in Workday. Insmed
Incorporated is an Equal Opportunity employer. We do not
discriminate in hiring on the basis of physical or mental
disability, protected veteran status, or any other characteristic
protected by federal, state, or local law. All qualified applicants
will receive consideration for employment without regard to sex,
gender identity, sexual orientation, race, color, religion,
national origin, disability, protected Veteran status, age, or any
other characteristic protected by law. It is unlawful in
Massachusetts to require or administer a lie detector test as a
condition of employment or continued employment. An employer who
violates this law shall be subject to criminal penalties and civil
liability. Unsolicited resumes from agencies should not be
forwarded to Insmed. Insmed will not be responsible for any fees
arising from the use of resumes through this source. Insmed will
only pay a fee to agencies if a formal agreement between Insmed and
the agency has been established. The Human Resources department is
responsible for all recruitment activities; please contact us
directly to be considered for a formal agreement. Insmed is
committed to providing access, equal opportunity, and reasonable
accommodation for individuals with disabilities in employment, its
services, programs, and activities. To request reasonable
accommodation to participate in the job application or interview
process, please contact us by email at TotalRewards@insmed.com and
let us know the nature of your request and your contact
information. Requests for accommodation will be considered on a
case-by-case basis. Please note that only inquiries concerning a
request for reasonable accommodation will be responded to from this
email address. Applications are accepted for 5 calendar days from
the date posted or until the position is filled.
Keywords: Insmed Incorporated, El Centro , Scientist II, Analytical Development, Bioassays, Science, Research & Development , San Diego, California
